Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly forms of cancer, primarily due to the resistance of PDAC tumors to current therapeutic strategies. Several lines of evidence suggest that ineffective delivery of chemotherapy agents t...
Published March 10, 2014

Familial Alzheimer's disease (FAD) is an early on-set, hereditary form of neurological disease with variable pathophysiology that is often associated with loss of cerebellar function and amyloid plaque formation. Diego Sepulveda-Falla and collea...
Published March 3, 2014

Vitamin A and its active metabolite retinoic acid (RA) are essential for lung formation, though it is not clear if prenatal vitamin A deficiency influences postnatal lung development and function. In this episode, Wellington Cardoso provides evidenc...
Published February 3, 2014

Nonsense mutations that lead to PAX6 haploinsufficiency cause congenital aniridia, a panocular condition that results in severe vision defects. Cheryl Gregory-Evans and colleagues hypothesized that suppression of nonsense mutations could in...
Published December 20, 2013

In order to protect the body from viruses and cancer, T cells must perform multiple functions, a feature that is often lost during chronic infection. Jonathan Schneck and colleagues examined the molecular mechanisms that maintain T cell polyfunction...
Published December 2, 2013

Damage to the glomerulus, which mediates the kidney's filtering function, causes plasma protein to spill into the urine, a sign of kidney failure and cardiovascular disease. Calcium influx into the podocytes, the cells that form the filtration b...
Published November 15, 2013

Results from early-phase clinical trials have indicated that recombinant adeno-associated viruses (rAAV) could potentially be used for gene therapy. In each trial, however, patients have developed T cell-mediated immune responses that may interfere ...
Published November 15, 2013

Researchers identify cellular mechanisms regulating cancer cell immunogenicity.
Published October 8, 2013

Researchers characterize antibodies that block H5N1 influenza viral transmission
Published September 3, 2013

Lindsey May and colleagues at the National Institute for Deafness and Other Communication Disorders examined how the hair cells of the inner ear respond to stress.
Published July 25, 2013